Best Supplements for Progesterone Support (2026) – Top 10 Reviewed
Progesterone is often called the “balancing hormone” because it plays a crucial role in menstrual cycle regulation, fertility, pregnancy maintenance, and overall hormonal harmony. When progesterone levels are low, you may experience irregular periods, PMS symptoms, fertility challenges, or difficulty maintaining pregnancy. This guide covers the best supplements specifically formulated to support healthy progesterone production and hormone balance naturally.
Our Top Picks at a Glance
- Best Overall: Gaia Herbs Pro Vitex — Premium liquid extract for enhanced absorption
- Best Value: Nature’s Way Vitex Fruit — Large 320-capsule supply
- Best Premium: Proov Pro — Targeted luteal phase support with multiple adaptogens
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Gaia Herbs Pro Vitex | Organic Vitex agnus-castus extract | Liquid Phyto-Caps | 30 | Overall progesterone support |
| Nature’s Way Vitex Fruit | Vitex agnus-castus 400mg | Capsules | 320 | Long-term value |
| Proov Pro | Vitex, Ashwagandha, Maca | Capsules | 60 | Fertility support |
| Gaia Herbs Vitex Berry | Organic Vitex extract with Agnuside | Liquid Phyto-Caps | 30 | Menstrual cycle support |
| Gaia Herbs Vitex Berry 120ct | Organic Vitex, FAIRWILD certified | Liquid Phyto-Caps | 60 | Extended supply |
| FLEUR Vitex Capsules | Vitex Chasteberry 500mg | Capsules | 60 | PCOS support |
1. Gaia Herbs Pro Vitex — Best Overall
- Chaste Tree Berry Extract Supplement: Our organic chaste tree berry extract provides a full spectrum herbal extract to support the maintenance of healthy hormone levels.*
- Supplement Aids Menopause Transition*: Our chaste tree supplement assists in supporting the transition into menopause and aids against discomfort from symptoms.*
- Premium Ingredients: Formulated with 500 mg of chaste tree berry per serving for women's health and healthy hormone support.*
- At Gaia Herbs PRO, our ingredients are rigorously tested to ensure that our herbs are harvested at the precise moment of peak potency. Then, we continuously test every single product to ensure integrity, purity, and potency from batch to bottle.
- Discover the Magic of Our Farm: Gaia Herbs operates nearly 270-acres of Regenerative Organic Certified land in North Carolina, growing over 5 million plants and 45 herbs each year. Anything we don’t grow ourselves is sourced from like-minded partners.
Gaia Herbs Pro Vitex delivers the highest quality organic chaste tree berry extract in their proprietary liquid phyto-cap format for maximum bioavailability.
This premium formula provides 1,000mg of organic Vitex agnus-castus berry extract standardized to 3mg of agnuside, the key active compound. The liquid extract format ensures superior absorption compared to dried herb capsules. Gaia Herbs uses FAIRWILD certified vitex berries and oversees every step from soil to supplement in their own facilities, ensuring unmatched purity and potency.
What We Like
- Liquid phyto-cap technology for enhanced absorption
- Standardized to contain 3mg agnuside per serving
- FAIRWILD certified and USDA organic
- Over 35 years of trusted supplement expertise
What Could Be Better
- Premium pricing compared to basic vitex supplements
- Results build over time, requiring 2+ months for best effects
Bottom Line: For women serious about supporting progesterone levels and willing to invest in premium quality, Gaia Pro Vitex offers the most bioavailable and effective formula available.
2. Nature’s Way Vitex Fruit — Best Value
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Nature’s Way provides an exceptional value with 320 capsules of quality vitex sourced from ideal growing regions.
Each capsule delivers 400mg of vitex fruit from regions with optimal climate conditions for vitex cultivation. With 320 capsules per bottle, this represents incredible value for long-term use. Nature’s Way has been a trusted name in herbal supplements for decades, and their vitex is vegan-friendly and rigorously tested for quality.
What We Like
- Outstanding value with 320 capsules per bottle
- Sourced from ideal climate regions for quality
- Vegan-friendly capsules
- Trusted brand with decades of expertise
What Could Be Better
- Not standardized for active compounds like some premium brands
- Dried herb may be less bioavailable than liquid extracts
Bottom Line: If you’re committed to long-term vitex supplementation and want the best cost per serving without sacrificing quality, Nature’s Way delivers excellent value.
3. Proov Pro — Best for Fertility Support
- SUPPORTS FERTILITY AND IMPLANTATION - Proov Pro is designed to support your body’s natural production of progesterone, a key hormone during the luteal phase of your cycle. Progesterone plays a vital role in successful ovulation, preparing your uterus for implantation, and maintaining a pregnancy. Empower your body with the support it needs for balanced hormone health.
- RELIEF FROM POOR SLEEP, TENSION, AND BRAIN FOG - Often called the "balancing hormone," progesterone is essential for maintaining harmony in your body and supporting a healthy menstrual cycle. Balanced progesterone levels can help ease symptoms of hormonal imbalance by supporting sleep and helping to improve tension and brain fog, making you feel more centered and in tune with your body.
- HOW IT WORKS - Proov Pro supports healthy progesterone levels and hormone balance. Progesterone levels naturally decline with age, so supporting healthy progesterone levels can help maintain optimal hormone balance.
- NATURAL HERBAL INGREDIENTS - Our vegan, non-GMO formula features time-honored botanicals like Vitex (Chasteberry), Ashwagandha Root, and Maca Root. These natural ingredients are known to support healthy progesterone levels, delivering the power of nature in convenient, easy-to-take capsules.
- RECOMMENDED USE - Our 30 capsules offer a 2-month supply, giving you more for less. Take Pro once daily during the last 15 days of your cycle when progesterone is naturally produced for optimal support. This natural herbal supplement is ideal for women seeking to promote healthy progesterone levels and for women not using fertility medications.
Proov Pro combines three powerful adaptogens specifically formulated to support progesterone production during the luteal phase.
This innovative formula brings together vitex (chasteberry), ashwagandha root, and maca root to naturally promote healthy progesterone levels. The supplement is designed to be taken during the last 15 days of your cycle when progesterone is naturally produced, optimizing support right when you need it most. It’s particularly beneficial for women trying to conceive or those experiencing luteal phase defects.
What We Like
- Triple-herb formula with complementary adaptogens
- Strategically timed for luteal phase support
- 30 capsules provide a full 2-month supply
- Made in USA in FDA-registered, GMP-compliant facility
What Could Be Better
- Requires cycle tracking to use optimally
- Not suitable for women using fertility medications
Bottom Line: For women actively trying to conceive or needing targeted luteal phase support, Proov Pro’s strategic formula offers comprehensive progesterone production support.
4. Gaia Herbs Vitex Berry — Best for Menstrual Support
- Menstrual Support Supplement: Vitex Berry is traditionally used for maintaining a healthy menstrual cycle*
- Hormone Balance for Women: Based on a rich history of traditional use, Gaia Herbs Vitex Berry helps maintain hormone balance in ovulating women*
- Chaste Tree Supplement: Made with FAIRWILD fair trade certified vitex berry
- Our Commitment to Quality: We thoughtfully source high-quality ingredients from around the world, guided by integrity and a deep respect for people, plants, and the planet
- About Gaia Herbs: For over 35 years, Gaia Herbs has helped people live healthier, more balanced lives by formulating products based on traditional herbal approaches while seeking support from modern science. We carefully oversee every step from soil to supplement to ensure purity, quality, and integrity you can trust.
This traditional formula specifically targets menstrual cycle regularity and hormone balance with premium organic vitex.
Gaia Herbs Vitex Berry provides organic chaste tree berry extract in their signature liquid phyto-capsule format, standardized to contain agnuside. The formula is traditionally used for maintaining healthy menstrual cycles and supporting hormone balance in ovulating women. Each serving delivers the therapeutic dose needed for menstrual cycle support.
What We Like
- Liquid phyto-caps ensure consistent absorption
- Traditionally used for menstrual cycle support
- Vegan, gluten-free, and dairy-free
- Made with FAIRWILD certified ingredients
What Could Be Better
- Only 30 servings per bottle
- Results take 2+ months to fully manifest
Bottom Line: Women dealing with irregular periods, PMS, or menstrual cycle irregularities will find this traditional formula provides reliable, time-tested support.
5. Gaia Herbs Vitex Berry 120ct — Best Extended Supply
- Menstrual Support Supplement: Vitex Berry is traditionally used for maintaining a healthy menstrual cycle*
- Hormone Balance for Women: Based on a rich history of traditional use, Gaia Herbs Vitex Berry helps maintain hormone balance in ovulating women*
- Chaste Tree Supplement: Made with FAIRWILD fair trade certified vitex berry
- Our Commitment to Quality: We thoughtfully source high-quality ingredients from around the world, guided by integrity and a deep respect for people, plants, and the planet
- About Gaia Herbs: For over 35 years, Gaia Herbs has helped people live healthier, more balanced lives by formulating products based on traditional herbal approaches while seeking support from modern science. We carefully oversee every step from soil to supplement to ensure purity, quality, and integrity you can trust.
This larger bottle provides 60 servings of Gaia’s premium liquid phyto-caps for extended progesterone support.
The 120-capsule bottle delivers the same high-quality organic vitex berry extract as Gaia’s smaller size but provides double the servings. With 60 full servings, this option offers better value for women committed to long-term supplementation. The liquid extract format ensures consistent potency and absorption throughout the entire bottle.
What We Like
- Double the servings for better long-term value
- Same premium liquid phyto-cap formula
- FAIRWILD certified for sustainable sourcing
- Backed by Gaia Herbs’ 35+ year reputation
What Could Be Better
- Higher upfront cost than smaller bottles
- May not be ideal for first-time users testing tolerance
Bottom Line: For women who’ve already experienced success with Gaia’s vitex formula and want to commit to ongoing support, this larger size offers excellent value.
6. FLEUR Vitex Capsules — Best for PCOS
FLEUR delivers 500mg of vitex chasteberry specifically formulated to support women with PCOS and hormonal imbalances.
This supplement provides a therapeutic dose of vitex agnus-castus to help maintain healthy progesterone levels, support regular menstrual cycles, and ease PMS symptoms. It’s particularly beneficial for women with PCOS who often struggle with hormonal imbalances and irregular cycles. The formula supports fertility while helping to regulate the menstrual cycle naturally.
What We Like
- 500mg therapeutic dose for PCOS support
- Helps regulate irregular menstrual cycles
- Supports both fertility and PMS relief
- Easy-to-swallow capsules
What Could Be Better
- Newer brand with less established reputation
- May require 3+ months for full PCOS benefits
Bottom Line: Women with PCOS seeking natural hormone balance support will appreciate this targeted formula designed to address their specific hormonal challenges.
How to Choose the Best Progesterone Support Supplement
Selecting the right progesterone support supplement requires understanding the key ingredients, quality markers, and your specific hormonal needs.
Prioritize vitex (chasteberry) as the primary ingredient. Vitex agnus-castus, also known as chasteberry or chaste tree berry, is the most well-researched and effective botanical for supporting progesterone production. It works by influencing the pituitary gland to reduce follicle-stimulating hormone (FSH) while increasing luteinizing hormone (LH), which in turn promotes progesterone production during the luteal phase. Look for supplements providing 400-1,000mg of vitex daily, ideally standardized to contain agnuside, the key active compound.
Consider extraction method and bioavailability. Liquid extracts and liquid phyto-capsules typically offer superior absorption compared to dried herb capsules. The extraction process concentrates the active compounds and makes them more bioavailable to your body. However, quality dried herb capsules can also be effective, especially when taken consistently over time. If choosing a liquid extract, look for standardization to specific percentages of active compounds like agnuside.
Look for complementary adaptogens and nutrients. While vitex is the star ingredient for progesterone support, some formulas enhance effectiveness with adaptogenic herbs like ashwagandha and maca root, which support overall hormonal balance and stress response. B vitamins, particularly B6, also support progesterone production and hormonal balance. These complementary ingredients can provide more comprehensive support, especially if you’re dealing with multiple hormonal symptoms.
Verify organic certification and sustainable sourcing. Because vitex berries accumulate compounds from their growing environment, organic certification ensures you’re not ingesting pesticides or synthetic fertilizers along with your supplement. FAIRWILD certification indicates the vitex was sustainably wild-harvested, protecting natural populations while ensuring quality. These certifications also typically correlate with higher overall supplement quality.
Understand timing and duration requirements. Vitex works gradually by supporting your body’s natural hormone production rather than providing quick symptom relief. Most women need to take vitex consistently for 2-3 months before experiencing full benefits, and some conditions like fertility issues may require 6+ months of use. Some formulas are designed for specific cycle phases (like luteal phase only), while others are taken daily throughout the month. Choose based on your specific needs and ability to commit to the regimen.
Benefits of Progesterone Support Supplements
Understanding how progesterone support supplements can help addresses your symptoms and sets realistic expectations for results.
Regulation of irregular menstrual cycles. One of the primary benefits of vitex supplementation is its ability to help normalize irregular periods. By supporting the body’s natural progesterone production, vitex can help establish more regular ovulation and menstruation. Women with cycles that are too long, too short, or unpredictable often find that vitex helps create more consistent 28-32 day cycles over time. This regulation typically becomes apparent after 2-3 cycles of consistent use.
Reduction in PMS and PMDD symptoms. Low progesterone during the luteal phase contributes significantly to premenstrual symptoms including mood swings, irritability, anxiety, breast tenderness, bloating, and sleep disturbances. By supporting healthy progesterone levels, vitex can significantly reduce these uncomfortable symptoms. Studies show that women taking vitex experience improvements in both physical and emotional PMS symptoms, with benefits becoming more pronounced over several months of use.
Enhanced fertility and luteal phase support. Progesterone is absolutely essential for successful conception and early pregnancy maintenance. A short luteal phase (less than 10 days between ovulation and menstruation) or inadequate progesterone production can prevent implantation or lead to early pregnancy loss. Vitex has been shown to increase progesterone levels during the luteal phase, lengthen short luteal phases, and improve overall fertility outcomes. Research indicates women taking vitex are approximately twice as likely to conceive compared to those not using it.
Support during menopause transition. While progesterone levels decline during perimenopause and menopause, maintaining adequate levels can help ease the transition. Vitex may help reduce hot flashes, night sweats, mood changes, and sleep disturbances associated with menopause. By supporting the body’s remaining progesterone production, vitex can provide natural relief during this hormonal transition without the risks associated with synthetic hormone replacement.
Frequently Asked Questions
How long does it take for vitex to increase progesterone levels?
Most women begin noticing improvements in symptoms within 2-3 menstrual cycles (about 6-12 weeks) of daily vitex supplementation. However, measurable increases in progesterone levels and full therapeutic benefits typically require 3-6 months of consistent use. Some conditions, particularly fertility challenges, may require 6-12 months of supplementation for optimal results. The key is patience and consistency—vitex works by gradually rebalancing your hormonal system rather than providing immediate effects.
Can I take vitex while trying to conceive?
Yes, vitex is commonly used to support fertility by improving progesterone production and luteal phase length. However, you should discontinue vitex once you confirm pregnancy, as there isn’t enough safety data for use during pregnancy. Many fertility specialists recommend taking vitex during the trying-to-conceive period but stopping it after a positive pregnancy test. Always consult with your healthcare provider, especially if you’re also undergoing fertility treatments.
What are the side effects of vitex supplements?
Vitex is generally well-tolerated, but some women may experience mild side effects, particularly when first starting. These can include digestive upset, headaches, acne (usually temporary as hormones rebalance), or changes in menstrual flow. In rare cases, vitex may increase period flow or cause mid-cycle spotting initially. These effects typically resolve within 1-2 cycles as your body adjusts. If side effects persist or worsen, discontinue use and consult a healthcare provider.
Can vitex help with PCOS symptoms?
Yes, vitex can be beneficial for women with PCOS, particularly those with irregular cycles or luteal phase defects. PCOS often involves hormonal imbalances including low progesterone, and vitex helps support natural progesterone production. Many women with PCOS report more regular cycles, improved fertility, and reduced PMS symptoms with vitex supplementation. However, PCOS is complex and usually requires a comprehensive treatment approach including diet, exercise, and possibly other supplements or medications.
Should I take vitex in the morning or evening?
Most experts recommend taking vitex in the morning, as this aligns with your body’s natural circadian hormone rhythms. The pituitary gland, which vitex influences, is most active in the morning hours. Taking your vitex supplement first thing in the morning on an empty stomach may enhance absorption and effectiveness. However, if morning dosing causes digestive upset, you can take it with breakfast instead.
Can men take vitex supplements?
While vitex is primarily used for women’s hormonal health, some men take it to help reduce excess prolactin levels, which can affect testosterone and fertility. However, men should only use vitex under medical supervision, as it can affect male hormone balance in unpredictable ways. The dosing and timing for men would differ significantly from women’s use, so professional guidance is essential.
Will vitex interfere with birth control pills?
Because vitex affects hormone levels, it may theoretically interfere with hormonal birth control methods including pills, patches, rings, and hormonal IUDs. If you’re using hormonal contraception, consult your healthcare provider before starting vitex. However, vitex can be beneficial for women experiencing symptoms as they transition off hormonal birth control, helping to reestablish natural hormonal balance and regular cycles.
Can I combine vitex with other hormone-balancing supplements?
Vitex can often be safely combined with other hormone-supporting supplements like evening primrose oil, magnesium, B vitamins, and certain adaptogens. However, be cautious about combining multiple herbs that directly affect hormone levels (like black cohosh, maca, or dong quai) without professional guidance. The effects can be unpredictable when multiple hormone-active herbs are used simultaneously. Start with vitex alone, assess your response, and then consider adding complementary supplements if needed.
