Best Supplements for Sinus Infections (2026) – Top 10 Reviewed
Sinus infections create miserable symptoms including facial pressure, congestion, and headaches that can drag on for weeks. While antibiotics may be necessary for bacterial sinus infections, the right supplements can support your body’s natural ability to fight infection, reduce inflammation, and promote drainage. This comprehensive guide reviews the most effective supplements for supporting sinus health and speeding recovery from sinus infections.
Our Top Picks at a Glance
- Best Overall: Premium Mullein Tea 60 Bags – respiratory and sinus support
- Best Value: NATURELO Vitamin D3 K2 – immune foundation for sinus health
- Best Premium: Designs for Health Quercetin – inflammation and histamine support
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Premium Mullein Tea | 100% Mullein Leaf | Tea Bags | 60 | Respiratory drainage |
| NATURELO D3 K2 | D3 2000IU, K2 MK-7 | Capsules | 60 | Immune support |
| Designs for Health Quercetin | Quercetin 500mg, Nettle | Capsules | 60 | Inflammation support |
| EZ Melts Vitamin C | Vitamin C 500mg | Melts | 60 | Immune boost |
| Metagenics Zinc A.G. | Zinc 15mg Chelated | Tablets | 180 | Infection fighting |
| Mushroom Gummies 4000mg | 26 Mushroom Blend | Gummies | 60 | Immune modulation |
| NATURELO Vitamin D 5000IU | Plant-based D3 | Capsules | 360 | Strong immune defense |
1. Premium Mullein Tea 60 Bags – Best Overall
- Grown in Clean, Untouched Fields: Sourced from pollution-free growing areas, our mullein leaves are cultivated without pesticides or harmful chemicals. Every batch is carefully processed to preserve its natural integrity.
- 100% Mullein Leaf – No Additives: Our mullein tea is made from 100% pure mullein leaf with no fillers, and no flavorings. Just clean, authentic herbs processed through a minimal, additive-free method to maintain full herbal value.
- Pure Plant-Based Tea Bags – No Plastic: We use only biodegradable, plant-based materials for our mullein tea bags— no staples, and no microplastics. A cleaner brew for both your body and the planet.
- Gentle Herbal Support with a Smooth Taste: This naturally caffeine-free herbal tea offers a mild, earthy flavor and is traditionally valued for its support of lung health and overall wellness. Enjoy hot or iced, on its own or with a hint of honey.
- Fast & Full Flavor in 4 Minutes: Made for convenience, our mullein tea delivers a rich and satisfying flavor within just 4–5 minutes of steeping. Whether you're in a hurry or taking time to unwind, this mullein leaf tea fits effortlessly into your routine.
Pure mullein leaf tea provides traditional respiratory and sinus support through mucus-thinning and anti-inflammatory properties.
Mullein has been used for centuries to support respiratory health and promote drainage of congested sinuses. This 100% pure mullein leaf tea helps thin mucus secretions, making it easier for your sinuses to drain naturally. The soothing properties also help reduce inflammation in irritated sinus passages while supporting overall lung and respiratory health.
What We Like
- 100% pure mullein leaf with no additives
- 60 tea bags provide 2-month supply
- Traditional herb with long history of respiratory support
- Helps promote natural sinus drainage
What Could Be Better
- Requires brewing time and preparation
- Earthy taste may not appeal to everyone
Bottom Line: Excellent traditional remedy for supporting sinus health through natural mucus-thinning and drainage promotion.
2. NATURELO Vitamin D3 K2 – Best Value
- BETTER TOGETHER: Vitamin D3 and K2 are perfect partners that work together to help your body absorb and use calcium properly, so that it goes into your bones -- and away from your arteries and soft tissues.*
- HEALTHY BONES & HEART: Vitamin D3 + K2 work together to support healthy bone density and healthy blood vessels for healthy circulation.* If you take calcium, adding D3 + K2 will support healthy calcium metabolism.*
- PLANT-BASED D3: Most Vitamin D3 supplements are made from lanolin secreted from sheep skin. Our vegan D-3 is completely plant-based and sustainably sourced from wild-harvested lichen.
- ACTIVE K2: Vitamin K2 as MK-7, a bioactive form of the vitamin that shows better bioavailability in humans and has well researched benefits for healthy bone building.*
- CLEAN LABEL: Made in a GMP compliant facility. Non GMO, vegetarian, vegan, and gluten free. Does NOT contain soy, dairy, yeast, eggs, nuts, caffeine, preservatives, or coloring.
Plant-based vitamin D3 and K2 combination provides essential immune support for fighting sinus infections.
Vitamin D plays a crucial role in immune function and helps your body fight the bacterial and viral infections that cause sinusitis. This vegan formula from lichen delivers bioavailable D3 paired with K2 for optimal absorption. Research shows adequate vitamin D levels reduce respiratory infection risk and support faster recovery from sinus issues.
What We Like
- 2000IU D3 ideal for immune support
- K2 MK-7 enhances absorption
- Plant-based and vegan-friendly
- Clean formula without synthetic additives
What Could Be Better
- Takes weeks to build optimal vitamin D levels
- May need higher dose if severely deficient
Bottom Line: Outstanding value for building immune defenses against sinus infections through essential vitamin D3 and K2.
3. Designs for Health Quercetin + Nettle – Best Premium
- Immune & Inflammatory Response Support - This formula delivers 600mg of Quercetin plus 600mg of Nettles in each serving. These two plant extracts have been shown to help the immune system, and the body's natural response to environmental challenges.*
- Why Quercetin? Quercetin has been called the king of flavonoids supplements, because of its powerful antioxidant properties. It helps the body regulate histamine.*
- Why Nettles? Nettle leaf has a high vitamin C content underlying its immune-supportive and antioxidant properties that may also benefit a normal inflammatory response.*
- Vegan & Non-GMO - These Nettle + Quercetin supplements are vegetarian and vegan-friendly. Made without GMOs, gluten, dairy, soy.*
- Over 50,000 Doctors Agree - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our Quercetin + Nettle supplement is based on the most recent research and use the highest quality raw ingredients.
Professional-grade quercetin and nettle formula supports healthy inflammatory response and histamine balance during sinus infections.
Quercetin is a powerful flavonoid that helps modulate inflammatory responses in sinus tissues while supporting healthy histamine levels. Combined with nettle leaf, which has natural antihistamine properties, this supplement addresses both infection-related inflammation and allergy-triggered sinus congestion. The professional Designs for Health quality ensures potency and purity.
What We Like
- 500mg quercetin reduces sinus inflammation
- Nettle supports healthy histamine response
- Professional-grade quality standards
- Addresses both infection and allergy triggers
What Could Be Better
- Premium pricing for professional quality
- Best results with consistent use
Bottom Line: Premium choice for comprehensive sinus support addressing inflammation, infection, and histamine issues.
4. EZ Melts Vitamin C – Fast Immune Boost
- Vitamin C Supplement: EZ Melts Vitamin C is formulated to dissolve quickly in your mouth, so keeping up with your health is easy and convenient
- Immune & Antioxidant Support: Formulated to provide antioxidant protection and immune support while supporting healthy energy levels*
- Overall Wellness & Skin Support: Vitamin C helps support collagen production, protect cells from oxidative stress, and support healthy skin and vitality*
- Daily Vitamin C Tablets: As a dietary supplement, take two dissolvable vitamin C tablets a day or as recommended by your healthcare professional
- Non-GMO & Vegan Supplement: EZ Melts makes it easier to take superior quality vitamins—free from artificial flavors, gluten, dairy, soy, and sugar
Quick-dissolving vitamin C tablets provide rapid immune support to help fight sinus infections.
The fast-melting format allows vitamin C to enter your bloodstream quickly, supporting white blood cell function critical for fighting sinus infections. At 500mg per serving, you can easily adjust dosage throughout the day to maintain therapeutic levels. Vitamin C also supports tissue healing in irritated sinus passages.
What We Like
- Fast-melting for rapid absorption
- 500mg allows flexible dosing
- No artificial ingredients
- Easy to take without water
What Could Be Better
- May need multiple doses for therapeutic effect
- Flavor preferences vary
Bottom Line: Excellent fast-acting vitamin C for supporting immune response during sinus infections.
5. Metagenics Zinc A.G. – Infection Fighting
- Superior Absorption: Provides zinc bound to arginine and glycine (amino acid chelates) for high absorption and gentle GI tolerance*
- Immune & Antioxidant Support: Essential for immune defense and antioxidant activity, helping protect cells from oxidative stress*
- Bone, Skin & Energy Metabolism: Supports bone health, tissue repair, healthy skin, and energy metabolism through zinc's role in over 300 enzymatic reactions*
- Clean and Trusted Formula: Non-GMO and gluten-free. Manufactured in GMP-certified facilities with third-party testing for purity and potency*
- As the #1 Doctor Recommended Professional Supplement Brand, Metagenics delivers clinically proven, precision-crafted formulas to support your health at its core‚ because true wellness starts with integrity, balance, and expertise
Highly absorbable chelated zinc supports immune function essential for fighting sinus infections.
Zinc is critical for immune cell development and function, helping your body mount an effective response to the bacteria or viruses causing sinusitis. This professional-grade formula uses chelation for superior absorption compared to standard zinc supplements. The 15mg dose provides optimal daily support for immune health.
What We Like
- Chelated form ensures maximum absorption
- 15mg ideal for immune support
- 180 tablets provide 6-month supply
- Professional Metagenics quality
What Could Be Better
- Tablet size may be large for some
- Premium pricing reflects quality
Bottom Line: Professional-grade zinc essential for immune defense against sinus infections.
6. Mushroom Gummies 4000mg – Immune Modulation
- ADVANCED NOOTROPIC MUSHROOM GUMMIES - 26 medicinal mushroom extracts, Ashwagandha, fermented black garlic, Ginkgo Biloba, and adaptogen herbs. A high-bioavailability formula designed for sustained focus, enhanced energy, immune support, and stress resilience. A perfect choice for students, professionals, fitness enthusiasts, and those seeking long-lasting brain support and stress relief. Support your wellness routine with just 3 sugar free mushroom gummies per day.*
- BRAIN SUPPLEMENTS FOR MEMORY AND FOCUS - A premium brain supplement with Lion's Mane, Bacopa Monnieri, and Ginkgo Biloba for memory, focus, and mental clarity. With Cordyceps, Rhodiola, and fermented Ginseng for physical energy, endurance, and mental fatigue relief. A comprehensive cognitive and immune defense formula for daily resilience, the perfect choice for maintaining a healthy, active lifestyle.
- IMMUNE & VITALITY SUPPORT - Our black garlic SAC and medicinal mushroom blend for enhanced bioavailability and overall wellness. Featuring Shiitake and Maitake for gut health and immunity; Cordyceps and Turkey Tail for natural energy and vitality; plus Milk Thistle for liver detox and repair. A simple, delicious daily boost—without capsules or powders.
- CALMING AND SOOTHING SUPPORT - Ashwagandha is an adaptogen herb, known for relaxation, stress relief, and mental alertness. A combination of Ashwagandha and saffron, supporting improved sleep, stress reduction, immune balance, athletic performance, mood stability, and cognitive health. A daily intake of mushroom gummies, promoting stress-free well-being.
- QUALITY YOU CAN TRUST - Experience the power of nature with our Elderberry-Flavored Mushroom Gummies! Each serving delivers a potent 4000mg mushroom blend, carefully crafted for maximum purity and potency. With no artificial colors or flavors, our supplement is vegan, non-GMO, and gluten-free. Each batch is third-party lab tested for purity and potency and proudly made in the USA.
Comprehensive blend of 26 medicinal mushrooms provides broad immune support for preventing and fighting sinus infections.
Medicinal mushrooms contain beta-glucans and other compounds that enhance immune function and support healthy inflammatory responses. This 4000mg blend includes varieties that research shows can help your body respond more effectively to infections. The convenient gummy format makes daily supplementation easy.
What We Like
- 26 mushroom varieties for comprehensive support
- 4000mg potent dose
- Pleasant-tasting gummies
- Supports balanced immune response
What Could Be Better
- Benefits accumulate over time
- Contains small amount of sugar
Bottom Line: Excellent broad-spectrum immune support for building resilience against recurrent sinus infections.
7. NATURELO Vitamin D 5000IU – Strong Immune Defense
- PLANT-BASED VITAMIN D3: Most vitamin D3 supplements are made from lanolin secreted from sheep skin. Our Vegan Vitamin D3 is sustainably sourced from wild-harvested lichen with no animal byproducts of any kind.
- HIGH POTENCY: 5000 IU of naturally bioactive Vitamin D3 can help restore blood levels in those who are deficient. Studies show that nearly half the U.S. population may be deficient in Vitamin D.*
- ESSENTIAL IMMUNE SUPPORT: Vitamin D is crucial for maintaining a healthy immune system.* Vitamin D levels may be especially low in winter or when you are stuck indoors.
- SUPPORTS BONE HEALTH: Vitamin D is necessary for your body to absorb calcium for strong bones and teeth. Risk of bone loss increases with age, particularly for women, and is also a risk during pregnancy.*
- CLEAN LABEL: Made in a GMP compliant facility. Non GMO, vegetarian, vegan, and gluten free. Does NOT contain soy, dairy, yeast, eggs, nuts, caffeine, preservatives, or coloring.
High-potency plant-based vitamin D3 provides therapeutic immune support for chronic or recurrent sinus infections.
This 5000IU formulation delivers therapeutic levels of vitamin D3 shown in research to significantly reduce respiratory infection risk. The plant-based sourcing from lichen makes it suitable for vegans while providing the same bioavailable D3 your body produces from sunlight. Particularly valuable for those with chronic sinusitis or frequent sinus infections.
What We Like
- 5000IU therapeutic dose
- Plant-based vegan D3
- Full year supply
- Research-backed for infection prevention
What Could Be Better
- Higher dose requires monitoring levels
- Takes weeks to build optimal levels
Bottom Line: Powerful high-potency vitamin D for those with recurrent sinus infections or vitamin D deficiency.
How to Choose the Best Supplements for Sinus Infections
Selecting effective supplements for sinus infections requires understanding both immune support and specific nutrients that address inflammation and drainage. Focus on ingredients that help your body fight infection while also supporting the natural processes that clear congested sinuses.
Start with immune-supporting nutrients like vitamin D, C, and zinc that help your body fight the bacterial or viral infections underlying most sinus problems. Vitamin D deficiency is strongly linked to increased respiratory infection risk, and supplementation can reduce both frequency and severity of sinus infections. If you’re prone to recurrent sinusitis, having your vitamin D levels tested makes sense.
Consider anti-inflammatory compounds like quercetin that help reduce swelling in sinus passages. Chronic inflammation keeps sinuses congested and prevents proper drainage, creating an environment where infections thrive. Quercetin and similar flavonoids support healthy inflammatory responses while also providing antihistamine effects that can help with allergy-triggered sinus issues.
Look for herbs with traditional use for respiratory and sinus support like mullein, which helps thin mucus and promote drainage. While research on these botanicals is still developing, their long history of traditional use and favorable safety profile makes them worth considering as part of a comprehensive approach to sinus health.
If you have recurrent sinus infections, probiotics may be worth adding to support overall immune function and potentially reduce infection frequency. Some research suggests certain probiotic strains can help prevent upper respiratory infections. Choose multi-strain formulas with at least 10 billion CFUs for best results.
Benefits of Sinus Infection Supplements
Taking targeted supplements during sinus infections can support your body’s natural healing processes while addressing the underlying immune dysfunction that allows infections to develop. The right nutrients help fight infection, reduce inflammation, and promote drainage that clears congested sinuses.
Immune-supporting supplements like vitamin D, C, and zinc enhance your body’s ability to fight the pathogens causing sinus infections. Research shows that people with adequate vitamin D levels experience fewer respiratory infections and recover more quickly when they do get sick. These nutrients support the production and function of immune cells that directly attack bacteria and viruses in your sinuses.
Anti-inflammatory nutrients help reduce the swelling that blocks sinus drainage and creates the stagnant environment where infections flourish. Quercetin and other flavonoids support healthy inflammatory responses without suppressing the immune activity needed to fight infection. This balanced approach helps your sinuses drain naturally while still allowing your immune system to work effectively.
Mucus-thinning herbs like mullein help break up thick secretions that block sinus passages. When mucus can flow more freely, your sinuses can drain properly, removing infected material and allowing fresh air to circulate. This natural drainage is essential for recovery and preventing infection from becoming chronic or spreading to other sinus cavities.
Frequently Asked Questions
What is the best supplement for sinus infections?
Vitamin D is the most important foundational supplement for sinus health, with research showing it reduces respiratory infection risk and supports immune function. However, the most effective approach combines vitamin D with vitamin C, zinc, and anti-inflammatory compounds like quercetin. For active infections, adding mullein tea or other drainage-promoting herbs can help clear congestion while your immune system fights infection.
Can supplements cure a sinus infection?
Supplements can’t cure sinus infections but they can support your body’s natural healing processes and may reduce symptom duration and severity. Bacterial sinus infections may still require antibiotics, while viral infections typically resolve with time and supportive care. Supplements work best as part of a comprehensive approach including hydration, rest, steam inhalation, and saline rinses.
How much vitamin C should I take for a sinus infection?
For active sinus infections, 1000-2000mg of vitamin C daily divided into multiple doses provides therapeutic immune support. Some people benefit from up to 3000mg, but spread this throughout the day as your body can only absorb limited amounts at once. Start supplementation at the first sign of sinus symptoms for best results. For prevention, 500-1000mg daily is typically sufficient.
Does vitamin D help with sinus infections?
Yes, vitamin D plays a critical role in immune function and research shows adequate levels reduce respiratory infection risk including sinusitis. Vitamin D helps regulate antimicrobial peptide production and supports immune cell function needed to fight sinus infections. If you have recurrent sinus infections, getting your vitamin D levels tested is worthwhile as deficiency significantly increases infection susceptibility.
What natural supplements help sinus drainage?
Mullein tea is excellent for promoting sinus drainage through its mucus-thinning properties. Quercetin helps reduce inflammation that blocks drainage. Vitamin C supports mucous membrane health. Bromelain enzyme from pineapple may help thin mucus. Combining these with plenty of hydration, steam inhalation, and saline rinses provides comprehensive drainage support.
Can probiotics help prevent sinus infections?
Some evidence suggests certain probiotic strains may reduce upper respiratory infection frequency, which could help prevent sinus infections. Probiotics support overall immune function and may help maintain healthy bacteria balance in respiratory passages. Look for multi-strain formulas with at least 10 billion CFUs. While research is still developing, probiotics are generally safe and may provide modest preventive benefits.
Should I take zinc for a sinus infection?
Yes, zinc supports immune function essential for fighting sinus infections and may help reduce infection duration. Take 15-30mg daily during acute infections, starting as early as possible for best results. Zinc helps immune cells function properly and has direct antimicrobial properties. Don’t exceed 40mg daily from all sources to avoid interfering with copper absorption.
How long should I take supplements for chronic sinusitis?
For chronic or recurrent sinusitis, maintain foundational supplements like vitamin D, C, and a quality multivitamin consistently for at least 3-6 months to support immune function. During acute flare-ups, add higher doses of vitamin C, zinc, and anti-inflammatory compounds. Work with a healthcare provider to address underlying causes like allergies or structural issues while using supplements for immune support.
