Best Supplements for White Blood Cells (2026) – Top 10 Reviewed
White blood cells are your body’s first line of defense against infections, viruses, and disease. Keeping these immune warriors healthy and functioning optimally is essential for overall wellness. If you’re looking to support your white blood cell production and activity, certain supplements have been scientifically proven to enhance immune function and strengthen your body’s natural defenses.
Our Top Picks at a Glance
- Best Overall: NATURELO Vitamin D – Plant-based immune support with clinical backing
- Best Value: Designs for Health Quercetin + Nettle – Dual-action immune enhancement
- Best Premium: BergaMet Citrus Bergamot SuperFruit – Advanced polyphenol formula
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| NATURELO Vitamin D | Vitamin D3 5000 IU | Capsules | 180 | Overall immune support |
| Designs for Health Quercetin | Quercetin 250mg, Nettle 200mg | Capsules | 60 | Antioxidant protection |
| BergaMet SuperFruit PRO+ | Bergamot 1350mg, Olive Leaf | Capsules | 60 | |
| Metagenics Zinc A.G. | Zinc 30mg with Arginine | Tablets | 180 | T-cell activation |
| EZ Melts Vitamin C | Vitamin C 1000mg | Melts | 60 | Rapid absorption |
| Mushroom Gummies 4000mg | 26 Mushrooms, Ashwagandha | Gummies | 60 | NK cell activity |
| drinkwel Multivitamin | B-Complex, Milk Thistle | Capsules | 90 | Comprehensive support |
| Iron Supplement Chelate | Iron 25mg, Vitamin C, B12 | Capsules | 60 | WBC production |
1. NATURELO Vitamin D – Best Overall
- PLANT-BASED VITAMIN D3: Most vitamin D3 supplements are made from lanolin secreted from sheep skin. Our Vegan Vitamin D3 is sustainably sourced from wild-harvested lichen with no animal byproducts of any kind.
- HIGH POTENCY: 5000 IU of naturally bioactive Vitamin D3 can help restore blood levels in those who are deficient. Studies show that nearly half the U.S. population may be deficient in Vitamin D.*
- ESSENTIAL IMMUNE SUPPORT: Vitamin D is crucial for maintaining a healthy immune system.* Vitamin D levels may be especially low in winter or when you are stuck indoors.
- SUPPORTS BONE HEALTH: Vitamin D is necessary for your body to absorb calcium for strong bones and teeth. Risk of bone loss increases with age, particularly for women, and is also a risk during pregnancy.*
- CLEAN LABEL: Made in a GMP compliant facility. Non GMO, vegetarian, vegan, and gluten free. Does NOT contain soy, dairy, yeast, eggs, nuts, caffeine, preservatives, or coloring.
NATURELO Vitamin D delivers 5000 IU of plant-based vitamin D3 from lichen, providing essential support for white blood cell activation and immune function.
This premium formula enhances the pathogen-fighting effects of monocytes and macrophages – crucial white blood cells that form your first line of defense. Clinical research shows vitamin D is essential for activating white blood cells and optimizing their ability to identify and destroy threats. The plant-based source ensures superior bioavailability compared to synthetic alternatives.
What We Like
- Plant-based D3 from sustainable lichen source
- High potency 5000 IU per serving supports optimal immune function
- Enhances macrophage and monocyte activity
- No synthetic ingredients or artificial additives
What Could Be Better
- Higher dose may not be suitable for everyone
- Requires consistent daily use for best results
Bottom Line: NATURELO Vitamin D provides science-backed immune support with clean, plant-based ingredients that effectively boost white blood cell function.
2. Designs for Health Quercetin + Nettle – Best for Antioxidant Protection
- Immune & Inflammatory Response Support - This formula delivers 600mg of Quercetin plus 600mg of Nettles in each serving. These two plant extracts have been shown to help the immune system, and the body's natural response to environmental challenges.*
- Why Quercetin? Quercetin has been called the king of flavonoids supplements, because of its powerful antioxidant properties. It helps the body regulate histamine.*
- Why Nettles? Nettle leaf has a high vitamin C content underlying its immune-supportive and antioxidant properties that may also benefit a normal inflammatory response.*
- Vegan & Non-GMO - These Nettle + Quercetin supplements are vegetarian and vegan-friendly. Made without GMOs, gluten, dairy, soy.*
- Over 50,000 Doctors Agree - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our Quercetin + Nettle supplement is based on the most recent research and use the highest quality raw ingredients.
This professional-grade formula combines quercetin with nettle leaf to provide powerful antioxidant protection while stimulating white blood cell production.
Quercetin is a potent flavonoid that has been shown to enhance immune cell function and reduce inflammation. When combined with nettle leaf, it creates a synergistic effect that supports natural killer cells and T-cell activity. The formula helps protect white blood cells from oxidative damage during immune responses while boosting their effectiveness against pathogens.
What We Like
- Professional-quality ingredients with clinical backing
- Quercetin supports NK cell and T-cell function
- Nettle leaf provides additional immune-boosting compounds
- Strong antioxidant protection for immune cells
What Could Be Better
- Premium pricing reflects professional-grade quality
- May cause mild digestive upset if taken on empty stomach
Bottom Line: A powerful combination that protects and enhances white blood cell function through scientifically validated ingredients.
3. BergaMet Citrus Bergamot SuperFruit PRO+ – Best Premium
- 80% POLYPHENOL PATENTED EXTRACTION: BergaMet’s patented extraction process compresses polyphenol-enriched powder into the maximum dosage and extract concentrations. Our formula has been clinically tested to contain over 80% polyphenols and is the only bergamot extract approved by Accademia del Bergamotto in Calabria, Italy.
- CITRUS SUPERFRUIT FORMULA: BergaMet PRO+ helps maintain optimal circulation and is a natural and effective way to support overall health - just 3 capsules a day can give you peace of mind.
- HAND PICKED IN CALABRIA, ITALY: Our Citrus Bergamot is hand-picked in Calabria Italy and processed at our patented extraction facility to ensure maximum purity and potency. Made and tested in a fully certified facility right here in the USA.
- EASY ON YOU: A fully organic, vegan friendly, diary, gluten, soy and GMO-free formula. Our Citrus Bergamot does not contain any sweeteners, artificial flavors, wheat, corn, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients.
BergaMet’s advanced formula delivers 1350mg of concentrated bergamot extract with 80% polyphenols, plus olive leaf extract for comprehensive immune support.
This premium supplement provides a unique 200:1 extract concentration, offering exceptional antioxidant protection for white blood cells. The high polyphenol content helps modulate immune responses while supporting overall cellular health. Olive leaf extract adds antimicrobial properties and further enhances white blood cell activity.
What We Like
- Exceptional 200:1 concentration ratio
- 80% polyphenols for maximum antioxidant benefit
- Olive leaf extract enhances immune function
- Supports both innate and adaptive immunity
What Could Be Better
- Premium price point
- Two capsules required per serving
Bottom Line: A sophisticated immune support formula that delivers superior antioxidant protection and white blood cell enhancement.
4. Metagenics Zinc A.G. – Best for T-Cell Activation
- Superior Absorption: Provides zinc bound to arginine and glycine (amino acid chelates) for high absorption and gentle GI tolerance*
- Immune & Antioxidant Support: Essential for immune defense and antioxidant activity, helping protect cells from oxidative stress*
- Bone, Skin & Energy Metabolism: Supports bone health, tissue repair, healthy skin, and energy metabolism through zinc's role in over 300 enzymatic reactions*
- Clean and Trusted Formula: Non-GMO and gluten-free. Manufactured in GMP-certified facilities with third-party testing for purity and potency*
- As the #1 Doctor Recommended Professional Supplement Brand, Metagenics delivers clinically proven, precision-crafted formulas to support your health at its core‚ because true wellness starts with integrity, balance, and expertise
This highly absorbable zinc formula with arginine and glycine chelates provides 30mg of zinc to support T-cell development and white blood cell production.
Zinc is essential for the differentiation and activation of T-cells, critical white blood cells that coordinate immune responses. The arginine and glycine chelation enhances absorption significantly compared to standard zinc supplements. Research shows zinc supplementation supports both innate immune cells like neutrophils and NK cells, as well as adaptive immune cells like T-cells and B-cells.
What We Like
- Superior chelated form for maximum absorption
- Supports T-cell and B-cell function
- Essential for white blood cell differentiation
- 180-serving bottle offers excellent value
What Could Be Better
- Should be taken with food to avoid nausea
- May interact with certain antibiotics
Bottom Line: An expertly formulated zinc supplement that provides critical support for T-cell activation and white blood cell development.
5. EZ Melts Vitamin C – Best for Rapid Absorption
- Vitamin C Supplement: EZ Melts Vitamin C is formulated to dissolve quickly in your mouth, so keeping up with your health is easy and convenient
- Immune & Antioxidant Support: Formulated to provide antioxidant protection and immune support while supporting healthy energy levels*
- Overall Wellness & Skin Support: Vitamin C helps support collagen production, protect cells from oxidative stress, and support healthy skin and vitality*
- Daily Vitamin C Tablets: As a dietary supplement, take two dissolvable vitamin C tablets a day or as recommended by your healthcare professional
- Non-GMO & Vegan Supplement: EZ Melts makes it easier to take superior quality vitamins—free from artificial flavors, gluten, dairy, soy, and sugar
EZ Melts delivers 1000mg of vitamin C in a fast-dissolving tablet that supports white blood cell production and function without artificial additives.
Vitamin C is crucial for stimulating the production of phagocytes and lymphocytes – key white blood cells that protect against infection. The melt-in-your-mouth format ensures rapid absorption and is ideal for those who have difficulty swallowing pills. Vitamin C also protects white blood cells from oxidative damage during immune responses.
What We Like
- Quick-dissolve format for fast absorption
- High-potency 1000mg per serving
- No artificial flavors or sweeteners
- Stimulates phagocyte and lymphocyte production
What Could Be Better
- Natural orange flavor may not appeal to everyone
- Higher doses may cause digestive sensitivity in some
Bottom Line: A convenient, fast-acting vitamin C supplement that effectively supports white blood cell production and activity.
6. Mushroom Gummies 4000mg – Best for NK Cell Activity
- ADVANCED NOOTROPIC MUSHROOM GUMMIES - 26 medicinal mushroom extracts, Ashwagandha, fermented black garlic, Ginkgo Biloba, and adaptogen herbs. A high-bioavailability formula designed for sustained focus, enhanced energy, immune support, and stress resilience. A perfect choice for students, professionals, fitness enthusiasts, and those seeking long-lasting brain support and stress relief. Support your wellness routine with just 3 sugar free mushroom gummies per day.*
- BRAIN SUPPLEMENTS FOR MEMORY AND FOCUS - A premium brain supplement with Lion's Mane, Bacopa Monnieri, and Ginkgo Biloba for memory, focus, and mental clarity. With Cordyceps, Rhodiola, and fermented Ginseng for physical energy, endurance, and mental fatigue relief. A comprehensive cognitive and immune defense formula for daily resilience, the perfect choice for maintaining a healthy, active lifestyle.
- IMMUNE & VITALITY SUPPORT - Our black garlic SAC and medicinal mushroom blend for enhanced bioavailability and overall wellness. Featuring Shiitake and Maitake for gut health and immunity; Cordyceps and Turkey Tail for natural energy and vitality; plus Milk Thistle for liver detox and repair. A simple, delicious daily boost—without capsules or powders.
- CALMING AND SOOTHING SUPPORT - Ashwagandha is an adaptogen herb, known for relaxation, stress relief, and mental alertness. A combination of Ashwagandha and saffron, supporting improved sleep, stress reduction, immune balance, athletic performance, mood stability, and cognitive health. A daily intake of mushroom gummies, promoting stress-free well-being.
- QUALITY YOU CAN TRUST - Experience the power of nature with our Elderberry-Flavored Mushroom Gummies! Each serving delivers a potent 4000mg mushroom blend, carefully crafted for maximum purity and potency. With no artificial colors or flavors, our supplement is vegan, non-GMO, and gluten-free. Each batch is third-party lab tested for purity and potency and proudly made in the USA.
This comprehensive blend of 26 medicinal mushrooms plus ashwagandha delivers 4000mg of immune-supporting compounds that enhance natural killer cell activity.
Medicinal mushrooms like shiitake, maitake, and reishi contain beta-glucans that have been clinically shown to activate NK cells and T-cells. Studies demonstrate that mushroom supplementation can increase NK cell activity by up to 38%. The addition of ashwagandha provides adaptogenic support to help modulate stress-related immune suppression.
What We Like
- 26 different mushroom varieties for comprehensive support
- Clinically proven to enhance NK cell activity
- Ashwagandha helps manage stress impact on immunity
- Great-tasting gummy format
What Could Be Better
- Contains small amount of natural sugar
- Two gummies required per serving
Bottom Line: A powerful mushroom blend that specifically targets natural killer cell function while providing broad-spectrum immune support.
7. drinkwel Multivitamin – Best Comprehensive Support
- THE ORIGINAL MULTIVITAMIN: Since 2010, we’ve provided the most comprehensive party product on the market. Fun nights, better mornings!
- RESTORE KEY NUTRIENTS: Drinkwel doesn’t cut corners and is loaded with Vitamin C, Thiamin, Vitamin B6, Folic Acid, Riboflavin, Copper, Magnesium and Selenium so you can replenish lost vitamins and minerals.
- LIVER SUPPORT AND MORE: In addition to the all-important Milk Thistle, our product goes the extra mile and contains Taurine, Schisandra, Artichoke, and Bupleurum (also known as Chinese Thoroughwax).
- DRINKWEL MEANS SUPERIOR QUALITY: Drinkwel is manufactured at a GMP-certified and NSF-approved facility in California, USA. All products are 3rd Party tested to the highest standards for quality and safety.
- FORMULATED BY DOCTORS: Created by two Berkeley graduates and formulated by a PhD in Biomedical Science and a Naturopathic Physician. Proudly featured on The Today Show, Complex, NY Mag, MSN, Men's Vogue, G4TV, Thrillist, and many more.
This complete multivitamin formula combines B-complex vitamins, milk thistle, and immune-supporting nutrients for comprehensive white blood cell support.
B vitamins, particularly B6 and B12, are essential for white blood cell production and function. This formula includes folic acid which helps produce white blood cells in the body. The addition of milk thistle supports liver health, which plays a crucial role in immune function and white blood cell production.
What We Like
- Complete B-complex for WBC production
- Milk thistle supports liver and immune health
- Multiple immune-supporting nutrients in one formula
- Third-party tested for purity
What Could Be Better
- Three capsules per serving
- Some users report mild stomach upset initially
Bottom Line: A well-rounded multivitamin that provides comprehensive nutritional support for white blood cell production and immune function.
8. Iron Supplement Chelate – Best for WBC Production
- GENTLE IRON FOR SENSITIVE STOMACHS - Our Chelated iron bisglycinate is clinically proven to be 3x more absorbable than regular iron sulfate, reducing the incidence of constipation, nausea and digestive discomfort that plague most iron supplements*
- DESIGNED FOR WOMEN'S UNIQUE NEEDS - Specifically formulated to support heavy menstrual cycles, pregnancy preparation and postpartum recovery. Includes folic acid for reproductive health and optimal iron absorption during your monthly cycle.
- BOOST ENERGY, FOCUS & CLARITY - Our high potency formula helps optimize energy levels and combat fatigue & brain fog, especially for women experiencing heavy menstrual cycles, or who have dietary restrictions, or high physical activity levels.
- FAST ACTING COMPLETE BLOOD BUILDER - Contains Ferrochel chelated iron (the gold standard), 5-MTHFR folate, Vitamin C, B6, and B12. One convenient capsule delivers everything your body needs to build healthy red blood cells naturally & quickly!
- PREMIUM QUALITY & SAFETY - Made in USA, third-party tested, vegan, non-GMO, and free from common allergens. 120-day supply with our satisfaction guarantee. Recommended by healthcare professionals for women with iron deficiency.
This gentle iron formula with vitamin C, B6, and B12 provides 25mg of chelated iron to support white blood cell production and oxygen transport.
Iron is essential for the production of hemoglobin and the development of white blood cells. The bisglycinate form is highly absorbable and gentle on the stomach. Vitamin C enhances iron absorption while B vitamins support the overall production of white blood cells. Folic acid helps produce and maintain new cells, including white blood cells.
What We Like
- Gentle chelated iron form (bisglycinate)
- Vitamin C enhances absorption significantly
- B-vitamins support WBC production
- Non-constipating formula
What Could Be Better
- Iron supplements can cause dark stools (harmless)
- Not suitable for those with iron overload conditions
Bottom Line: An expertly formulated iron supplement that supports white blood cell production with enhanced absorption and minimal side effects.
How to Choose the Best White Blood Cell Supplement
When selecting a supplement to support your white blood cells, several key factors should guide your decision. First, consider the specific type of white blood cell support you need. Some supplements primarily enhance innate immune cells like neutrophils and macrophages, while others focus on adaptive immune cells like T-cells and B-cells.
Look for supplements with clinically studied ingredients at therapeutic doses. Vitamin D should be at least 2000-5000 IU, vitamin C at 500-1000mg, and zinc at 15-30mg for immune support. Quality matters – choose supplements from reputable manufacturers that undergo third-party testing for purity and potency.
Consider the bioavailability of the nutrients. Chelated minerals like zinc glycinate or bisglycinate iron are absorbed much more effectively than cheaper oxide forms. Fat-soluble vitamins like vitamin D should ideally be paired with a source of healthy fat for optimal absorption.
Pay attention to potential interactions with medications or existing health conditions. For example, high-dose vitamin C may interact with certain chemotherapy drugs, and zinc can interfere with antibiotic absorption. Always consult with your healthcare provider before starting any new supplement regimen.
Finally, consider convenience and compliance. Choose a format you’ll actually take consistently – whether that’s capsules, gummies, melts, or powders. The best supplement is one you’ll use regularly as directed.
Benefits of White Blood Cell Supplements
Supporting your white blood cells through targeted supplementation offers numerous science-backed benefits for your immune system and overall health. White blood cells are your body’s primary defense against infections, and keeping them functioning optimally is crucial for staying healthy.
Enhanced immune response is the most direct benefit. Supplements like vitamin D and zinc have been shown to activate white blood cells more quickly when threats are detected. This means your body can respond faster and more effectively to viruses, bacteria, and other pathogens before they can establish infections.
White blood cell supplements also provide antioxidant protection during immune responses. When white blood cells attack pathogens, they produce reactive oxygen species that can damage the immune cells themselves. Antioxidants like vitamin C, vitamin E, and quercetin protect white blood cells from this oxidative stress, allowing them to function longer and more effectively.
Improved production and differentiation of white blood cells is another key benefit. Nutrients like B vitamins, iron, and zinc are essential for the bone marrow to produce new white blood cells. Adequate supplementation ensures your body can maintain healthy white blood cell counts, especially important during periods of stress or illness when demand increases.
Frequently Asked Questions
What supplements increase white blood cells naturally?
Vitamin D, zinc, vitamin C, selenium, and B vitamins are the most effective supplements for naturally increasing white blood cell production and function. Vitamin D activates monocytes and macrophages, zinc supports T-cell development, and vitamin C stimulates phagocyte production. Medicinal mushrooms containing beta-glucans have also been clinically shown to enhance white blood cell activity, particularly natural killer cells.
How long does it take for supplements to increase white blood cells?
Most people see improvements in white blood cell function within 2-4 weeks of consistent supplementation, though production increases may take 4-8 weeks to reflect in blood tests. Rapid-acting nutrients like vitamin C can enhance white blood cell activity within hours to days, while minerals like zinc and selenium require several weeks to reach optimal tissue levels and fully support white blood cell development.
Can you take multiple white blood cell supplements together?
Yes, most white blood cell supplements work synergistically and can be safely combined. In fact, nutrients like vitamin C and iron work better together, as vitamin C enhances iron absorption. However, timing matters – zinc and iron should be taken separately as they compete for absorption. Always consult your healthcare provider before combining multiple supplements, especially if you take medications.
What are the signs of low white blood cells?
Frequent infections, slow wound healing, persistent fatigue, recurring fevers, and mouth sores can all indicate low white blood cell counts. If you experience these symptoms regularly, consult your doctor for blood work rather than self-treating with supplements. Low white blood cell counts (leukopenia) can have serious underlying causes that require medical attention.
Do white blood cell supplements help with autoimmune conditions?
White blood cell supplements can help modulate immune function, but their use in autoimmune conditions requires careful medical supervision. While nutrients like vitamin D and omega-3 fatty acids may help balance immune responses, other supplements that stimulate white blood cells could potentially worsen certain autoimmune conditions. Always work with your healthcare provider to determine appropriate supplementation for autoimmune disorders.
Are there any side effects from white blood cell supplements?
Most white blood cell supplements are safe when taken at recommended doses, but some can cause side effects. High-dose vitamin C may cause digestive upset, zinc can cause nausea if taken on an empty stomach, and excessive vitamin D can lead to calcium imbalances. Iron supplements commonly cause constipation or dark stools. Start with lower doses and increase gradually to minimize side effects.
How do I know if white blood cell supplements are working?
You may notice fewer colds and infections, faster recovery from illness, improved energy levels, and better overall health. Clinical confirmation requires blood work showing improved white blood cell counts and function. Many people report subjective improvements in how they feel within 2-4 weeks, though measurable changes in blood work typically take 4-8 weeks of consistent supplementation.
Should I take white blood cell supplements year-round?
For most people, year-round supplementation with foundational nutrients like vitamin D and a quality multivitamin provides consistent immune support. You can increase dosages or add targeted supplements during cold and flu season, periods of high stress, or when recovering from illness. Some practitioners recommend cycling certain immune-stimulating supplements rather than taking them continuously, though essential nutrients like vitamin D are safe and beneficial for daily use.
