Best TMG Supplements
Trimethylglycine (TMG), also known as betaine anhydrous, has gained significant attention for its role in supporting methylation, cardiovascular health, and athletic performance. This comprehensive guide examines the top TMG supplements available to help you find the best option for your health goals and budget.
Our Top Picks at a Glance
- Best Overall: Double Wood Supplements TMG – Genuine formula with fishy smell verification
- Best Value: Best Naturals TMG Powder – Most affordable per-serving cost
- Best Premium: Allergy Research Group TMG – 750mg high-strength hypoallergenic formula
Quick Comparison
| Product | Dosage | Form | Servings | Best For |
|---|---|---|---|---|
| Double Wood TMG | 1000mg | Capsules | 180 | Overall value |
| Best Naturals Powder | Variable | Powder | 454g | Budget-conscious |
| Allergy Research TMG | 750mg | Capsules | 100 | Sensitive individuals |
| 10X Health TMG | 1000mg | Capsules | 60 | Heart health focus |
| Best Naturals Capsules | 1000mg | Capsules | 120 | Convenience |
| Mchokuu L-Methylfolate Gummies | 400mg TMG | Gummies | 120 | Methylation support |
1. Double Wood Supplements TMG – Best Overall
- SUPPORTS ACTIVE LIFESTYLE: TMG capsules may support active lifestyle and overall physical performance
- TMG SUPPLEMENTS TO LOWER HOMOCYSTEINE: Multiple studies show that supplementing with TMG (Trimethylglycine) in doses of 3,000mg may reduce homocysteine levels by up to 40%
- GENUINE TMG WITH FISHY SMELL: Real TMG inherently has a fishy odor. Do not be alarmed by the smell as it is evidence the product you received is genuine TMG.
- COMBINE WITH OUR METHYLATED MULTIVITAMIN FOR CARDIOVASCULAR HEALTH: TMG is the perfect ingredient to combine with our Methylated Multivitamin to support cardiovascular health
- WE BOTTLE WELLNESS: At Double Wood, we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing.
With 1000mg per serving and a genuine fishy odor that verifies authentic TMG, this formula delivers proven homocysteine support at an excellent value.
Double Wood Supplements provides 1000mg of pure trimethylglycine per capsule in a 180-count bottle. The company emphasizes that genuine TMG has a characteristic fishy smell, which serves as authentication that you’re getting real betaine anhydrous rather than fillers. Research shows that 3000mg daily of TMG can reduce homocysteine levels by up to 40%, making this three-capsule protocol effective for cardiovascular support. The formula is gluten-free, non-GMO, and third-party tested for purity and potency.
What We Like
- Authentic TMG verified by characteristic fishy odor
- 1000mg per capsule allows flexible dosing
- 180-capsule count provides 60-180 day supply
- Third-party tested for quality assurance
- Excellent value per serving
What Could Be Better
- Fishy smell may be off-putting to some users
- Requires multiple capsules for clinical doses
Bottom Line: A high-quality, authentic TMG supplement that delivers proven cardiovascular benefits at a competitive price point with verified purity.
2. Best Naturals TMG Powder – Best Value
- 3rd Party Lab Tested for Purity & Quality.
- 2000 mg of Betaine Anhydrous per Serving - 227 Servings per Container.
- Non-GMO & Gluten Free.
- Proudly Made in USA, GMP Compliant, FDA Registered Facility.
- No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Milk, No Corn, No Soy, No Egg, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.
This pure betaine anhydrous powder offers the lowest cost per serving, allowing you to customize dosage while maximizing value.
Best Naturals provides pure trimethylglycine powder in a 1-pound container, offering maximum flexibility and value. The unflavored powder can be mixed into water, juice, or smoothies, though it does have a slightly sweet taste. This format is ideal for those taking higher doses (3-6 grams daily) as recommended by research for cardiovascular and athletic performance benefits. The powder is non-GMO, gluten-free, and manufactured in a GMP-compliant facility in the USA.
What We Like
- Lowest cost per serving of any TMG supplement
- Easy to adjust dosage precisely
- Pure powder with no unnecessary additives
- Large 1-pound size lasts months
- Non-GMO and gluten-free
What Could Be Better
- No scoop included for measuring
- Powder form less convenient than capsules
Bottom Line: The most economical TMG option available, perfect for those who don’t mind powder supplements and want maximum value.
3. Allergy Research Group TMG – Best Premium
- Methylation Support: Allergy Research Group TMG provides trimethylglycine to support natural methylation pathways and homocysteine metabolism for daily wellness*
- Cellular and Liver Health: Supports cellular osmotic balance and helps maintain natural processes involved in liver and kidney function for overall well being*
- High-Strength TMG: Delivers 750 mg per capsule of trimethylglycine to support nutrient conversion pathways, including methionine and dimethylglycine formation*
- Highest Purity Standards: This supplement is free from gluten, dairy, soy, corn, nuts, egg, shellfish, fish, sesame and yeast
- Solutions Backed by Science: Allergy Research Group and its family of brands—Metabolic Maintenance, MethylPro, Nutricology and Optimox—have delivered trusted supplements for more than 45 years
Delivering 750mg of pharmaceutical-grade trimethylglycine in a hypoallergenic formula, this premium option suits those with sensitivities.
Allergy Research Group has provided trusted supplements for over 45 years, and their TMG capsules maintain their reputation for quality. Each capsule contains 750mg of trimethylglycine to support methylation pathways and homocysteine metabolism. The formula is free from gluten, dairy, soy, and other common allergens, making it suitable for individuals with multiple sensitivities. The company emphasizes pharmaceutical-grade ingredients and rigorous quality control throughout manufacturing.
What We Like
- Pharmaceutical-grade trimethylglycine
- Hypoallergenic formula free from common allergens
- 750mg strength allows flexible dosing
- 45+ years of supplement manufacturing experience
- Vegetarian-friendly capsules
What Could Be Better
- Higher price point than other brands
- Only 100 capsules per bottle
Bottom Line: A premium TMG supplement ideal for those with sensitivities who want pharmaceutical-grade quality and hypoallergenic formulation.
4. 10X Health TMG Supplements – Best for Heart Health
- Better Heart Health: Support heart health with 10X TMG, a trimethylglycine supplement rich in glycine betaine to support good homocysteine levels and methylation. Trusted homocysteine supplements for heart support and methylated vitamins synergy.
- Supports Optimal Homocysteine Levels: Backed by science, our high-potency TMG supplement helps maintain optimal homocysteine levels. Use with homocysteine supplements for complete support and overall wellness.
- Clean Amino Acids for Wellness: Formulated with 1000mg betaine TMG (per 2-capsule serving) and glycine betaine, these TMG supplements 1000mg support liver function, methylation cycles, and cellular balance, crafted for long-term wellness and vitality.
- Boosts Energy and Vitality: Supercharge your vitality with 10X TMG, crafted to support energy, mitochondrial health, and performance. Powered by Betaine Anhydrous, it’s your go-to betaine TMG for strength, stamina, and complete cellular function.
- Quality and Safety Assured: The 10X TMG Supplements from 10X Health System are made with premium ingredients, put through careful testing to ensure potency and purity, and are perfect for people looking to take control of their health and wellness.
Specifically marketed for cardiovascular wellness, this 1000mg formula emphasizes heart health and homocysteine level support.
10X Health focuses on comprehensive wellness through targeted supplementation, and their TMG capsules deliver 1000mg of betaine anhydrous per serving (2 capsules). The formula is designed to support healthy homocysteine levels, which play a crucial role in cardiovascular function. Each bottle contains 60 capsules (30 servings), and the product is non-GMO and gluten-free. The company emphasizes the synergy between TMG and methylated vitamins for optimal heart support.
What We Like
- Focused on cardiovascular health benefits
- 1000mg per 2-capsule serving
- Clean formula without unnecessary additives
- Non-GMO and gluten-free certification
- Clear dosing instructions for heart support
What Could Be Better
- Smaller bottle size than competitors
- Requires 2 capsules per serving
Bottom Line: An excellent choice for those specifically seeking TMG for cardiovascular support, with clear heart health messaging and quality ingredients.
5. Best Naturals TMG Capsules – Best for Convenience
- 3rd Party Lab Tested for Purity & Quality.
- 1000 mg of TMG per Servings - 60 Servings & 120 Capsules per Bottle
- Non-GMO & Gluten Free.
- Proudly Made in USA, GMP Compliant, FDA Registered Facility.
- No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Milk, No Corn, No Soy, No Egg, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.
With 1000mg per serving in easy-to-swallow capsules, this formula provides authentic TMG in a convenient format.
Best Naturals offers their TMG in capsule form for those who prefer convenience over powder. Each serving (2 capsules) provides 1000mg of trimethylglycine, supporting healthy homocysteine levels and methylation. The 120-capsule bottle provides a 60-day supply at the recommended dose. The formula is non-GMO, gluten-free, and manufactured in an FDA-registered, GMP-compliant facility with no artificial colors, flavors, or preservatives.
What We Like
- Convenient capsule format
- 1000mg per 2-capsule serving
- No artificial ingredients or preservatives
- Made in FDA-registered facility
- Good value for capsule format
What Could Be Better
- More expensive per serving than powder
- Contains bovine gelatin (not vegetarian)
Bottom Line: Perfect for those who want TMG in a convenient capsule format without the hassle of measuring powder, at a reasonable price point.
6. Mchokuu L-Methylfolate Gummies with TMG – Best Combo Formula
- Advanced Formula: Each serving provides 1000mcg L-Methylfolate (active 5-MTHF) + 2.4mcg of methyl B12 to support the MTHFR gene & healthy methylation cycle. Also contains 400mg choline & 400mg betaine (TMG) to help neurotransmitters & mood balance
- Multiple Benefits: Features 700mg Omega-3 (3:1 DHA: EPA) plus Choline for neural health, memory & focus. Methyl B12 & TMG work synergistically to promote healthy homocysteine levels & provide lasting nutritional support for optimal brain function
- Energy & Mood Support: Active 5-MTHF helps to make "feel-good" chemicals called neurotransmitters like serotonin and dopamine. This formula helps the body convert food into energy, combat fatigue, boost daily levels of energy and improve mood
- Sugar-Free & Vegan: The methylfolate supplement gummies are crafted with a sugar-free, non-GMO & vegan formula. Easy to chew & swallow and making them an ideal addition to your daily routine. We are proud to present a reliable choice for your health
- Family-Friendly Formula: A 60-count-gummy bottle provides 2 months of daily assistance. Methylfolate for kids & adults supports brain health, energy, mood & methylation. The mthfr supplement for cellular function & overall wellness!
Combining 400mg TMG with 1000mcg L-methylfolate, methyl B12, choline, and omega-3s, these raspberry gummies support comprehensive methylation.
Mchokuu takes a comprehensive approach to methylation support by combining TMG with other key nutrients in a tasty gummy format. Each serving provides 400mg of betaine (TMG) alongside 1000mcg of active L-methylfolate (5-MTHF), 2.4mcg methyl B12, 400mg choline, and 700mg omega-3 fatty acids from algae oil. This synergistic formula is specifically designed for individuals with MTHFR gene variations who need enhanced methylation support. The sugar-free raspberry flavor makes daily supplementation enjoyable.
What We Like
- Comprehensive methylation support formula
- Includes TMG, methylfolate, B12, choline, and omega-3s
- Pleasant raspberry flavor in gummy form
- Designed for MTHFR gene support
- Vegan and sugar-free
What Could Be Better
- Lower TMG dose than standalone supplements
- More expensive due to multiple ingredients
Bottom Line: An excellent all-in-one methylation support supplement that combines TMG with complementary nutrients in a tasty, convenient gummy format.
How to Choose the Best TMG Supplement
When selecting a TMG supplement, your first consideration should be the dosage and form that aligns with your health goals. Research indicates that effective doses for cardiovascular support typically range from 3-6 grams (3000-6000mg) daily, while athletic performance benefits may be seen with 1.5-3 grams daily. If you’re taking higher doses, powder forms like Best Naturals offer the best value and easiest dosing flexibility. For standard maintenance doses of 1-2 grams, capsules provide unmatched convenience.
Consider the purity and authenticity of the product. Genuine TMG has a characteristic fishy odor due to its chemical structure – this is actually a quality indicator rather than a defect. Brands like Double Wood explicitly mention this smell as verification of authenticity. Look for third-party testing certifications, GMP manufacturing, and companies with established reputations in the supplement industry. Avoid products with unnecessary fillers, artificial ingredients, or proprietary blends that don’t disclose exact TMG amounts.
Evaluate your dietary restrictions and sensitivities. Most TMG supplements are naturally gluten-free and non-GMO, but some capsules contain gelatin (not suitable for vegetarians) while others use vegetarian capsules. Allergy Research Group specifically caters to those with multiple sensitivities by ensuring their formula is free from common allergens. If you have specific dietary requirements, verify the ingredient list carefully before purchasing.
Think about your budget and cost per serving. While capsules offer convenience, powder forms typically provide significantly lower cost per gram of TMG. Calculate the actual cost per 1000mg serving across different products to make accurate comparisons. Subscribe-and-save options on Amazon can reduce costs by 10-15%, making regular supplementation more affordable. Consider that a 3-month supply often offers better value than monthly purchases.
Determine whether you want standalone TMG or a combination formula. Pure TMG supplements allow you to control dosage precisely and combine with other supplements as needed. However, combination formulas like the Mchokuu gummies provide synergistic nutrients that work together for enhanced methylation support, which may be more convenient if you’re addressing specific genetic variations like MTHFR or want comprehensive homocysteine management.
Benefits of TMG Supplements
The primary benefit of TMG supplementation is its powerful support for healthy homocysteine levels. Elevated homocysteine is associated with increased cardiovascular risk, and research demonstrates that TMG doses of 3-6 grams daily can reduce homocysteine by 20-40%. TMG works by donating methyl groups in the conversion of homocysteine to methionine, effectively lowering circulating homocysteine levels. This methylation support is particularly valuable for individuals with genetic variations (like MTHFR polymorphisms) that impair normal homocysteine metabolism.
Athletic performance enhancement represents another well-documented benefit of TMG supplementation. Studies show that 1.25-2.5 grams of TMG taken twice daily can increase muscle power output by up to 90% during squat exercises, similar to the effects of creatine monohydrate. TMG supports physical performance through multiple mechanisms: it enhances creatine production in the body, supports protein synthesis, and may improve cellular hydration. Athletes and fitness enthusiasts use TMG to boost strength, power, and recovery from intense training.
Liver health and detoxification support make TMG valuable beyond cardiovascular and athletic applications. As a major methyl donor, betaine plays crucial roles in liver function, including fat metabolism and bile production. Research indicates that TMG may help prevent fatty liver disease and support the liver’s natural detoxification processes. This makes it particularly relevant for individuals concerned about liver health or those exposed to environmental toxins that increase methylation demands.
Cellular methylation throughout the body depends on adequate methyl group availability, which TMG helps provide. Proper methylation is essential for DNA synthesis, neurotransmitter production, hormone metabolism, and countless other biochemical processes. By serving as a backup methyl donor when folate-dependent pathways are insufficient, TMG ensures cellular processes continue functioning optimally. This broad methylation support can influence energy levels, mood stability, and overall cellular health.
Frequently Asked Questions
What is the best time to take TMG supplements?
TMG can be taken at any time of day with or without food, though many users prefer taking it with meals to enhance absorption and minimize any potential stomach upset. For athletic performance benefits, some research suggests taking TMG 30-60 minutes before workouts. If taking multiple doses daily, spacing them throughout the day (morning and evening) maintains more stable blood levels.
How much TMG should I take daily?
Typical doses range from 500mg to 6000mg daily depending on your goals. For general methylation support, 500-1500mg daily is common. Cardiovascular support and homocysteine reduction typically require 3000-6000mg daily based on research. Athletic performance benefits are seen with 1500-5000mg daily. Always start with lower doses and increase gradually while monitoring your response.
Can TMG cause side effects?
TMG is generally well-tolerated, but some individuals may experience mild digestive upset, nausea, or diarrhea at higher doses (above 6 grams daily). The characteristic fishy odor is normal for authentic TMG. Rarely, some users report changes in body odor. These effects are typically mild and resolve with dosage reduction. Consult your healthcare provider if you experience persistent side effects.
Is TMG the same as betaine HCl?
No, TMG (betaine anhydrous) and betaine HCl are different compounds with different uses. TMG is a methyl donor used for cardiovascular support, athletic performance, and methylation. Betaine HCl is primarily used as a digestive aid to increase stomach acid. While they’re chemically related, they serve distinct purposes and are not interchangeable.
Can I take TMG with other supplements?
Yes, TMG is commonly combined with other methylation-supporting nutrients like methylfolate, methyl B12, and choline for enhanced benefits. It also works synergistically with creatine monohydrate. However, avoid combining TMG with other high-dose methyl donors without professional guidance, as excessive methylation can cause adverse effects. Always consult a healthcare provider before combining supplements, especially if you take medications.
Do I need TMG if I eat a healthy diet?
While TMG is found naturally in foods like beets, spinach, and whole grains, dietary intake typically provides only 100-300mg daily – far below therapeutic doses used in research. If you have elevated homocysteine levels, MTHFR genetic variations, specific athletic goals, or increased methylation demands, supplementation may be beneficial beyond what diet alone provides.
How long does it take to see results from TMG?
Results vary by application. Athletic performance improvements may be noticed within 1-2 weeks of consistent use. Homocysteine level reductions typically become measurable after 4-6 weeks of supplementation at adequate doses (3-6 grams daily). For general methylation support and liver health, benefits accumulate over months of regular use. Blood testing can objectively track homocysteine changes.
Should I cycle TMG or take it continuously?
Unlike some supplements, TMG is generally safe for continuous long-term use at recommended doses. Research studies have used TMG continuously for months to years without requiring cycling. However, it’s wise to periodically reassess your need through blood work (homocysteine levels) and adjust dosage accordingly. Some athletes cycle TMG around training periods, but this isn’t necessary for cardiovascular or methylation support.
