Best Urolithin A Supplements for Longevity (2026) – Top 10 Reviewed
Urolithin A has become one of the most talked-about longevity compounds in recent years, with clinical research showing it can boost mitochondrial function, improve muscle strength, and support healthy aging at the cellular level. Unlike many supplements, urolithin A has real science behind it—multiple human trials demonstrating measurable benefits.
The challenge? Only about 40% of people can naturally produce urolithin A from food sources like pomegranates. That’s where supplementation comes in. We’ve evaluated dozens of options to find the best urolithin A supplements based on purity, dosage, absorption technology, and value. Here are our top 10 picks for 2026.
| Product | Key Ingredients | Servings | Form | Best For |
|---|---|---|---|---|
| Timeline Mitopure Softgels | 500mg Mitopure Urolithin A | 60 | Softgels | Best Overall |
| Timeline Mitopure Gummies | 500mg Mitopure Urolithin A | 30 | Gummies | Best Tasting |
| Codeage Liposomal Urolithin A | 500mg UA + Resveratrol, CoQ10 | 30 | Capsules | Best Synergistic Formula |
| Timeline Mitopure Powder | 500mg Mitopure Urolithin A | 30 | Powder | Best for Smoothies |
| NAD Supplement 8457mg with Urolithin A | Urolithin A, NMN, Resveratrol, CoQ10 | 60 | Capsules | Best Multi-Longevity Stack |
| Urolithin A Complex with NR | Urolithin A, NR, Resveratrol, CoQ10, PQQ | 60 | Capsules | Best for Beginners |
| NMN Supplement 8957mg with Urolithin A | Urolithin A, NMN, Resveratrol, CoQ10, ALA | 60 | Capsules | Best High-Potency Stack |
| MITIVA Urolithin A with NAD+ | Urolithin A, NAD+, CoQ10, PQQ | 120 | Softgels | Best Value |
| Rasav NAD 10-in-1 with Urolithin A | Urolithin A, NAD, Resveratrol, CoQ10, ALA | 60 | Capsules | Best Budget Multi-Nutrient |
| Prominent Nutrition Urolithin A + Fisetin | 600mg Urolithin A + Fisetin | 60 | Capsules | Best Pure Formula |
1. Timeline Mitopure Softgels – Best Overall
Why it stands out: Timeline’s Mitopure is the gold standard in urolithin A supplementation—it’s the only form with multiple published clinical trials and FDA GRAS status. The company behind it invented the patented Mitopure formulation after 15+ years of research.
Each serving delivers 500mg of highly pure, clinically validated Mitopure urolithin A. Clinical studies show this dose can increase muscle strength by up to 12% and endurance by up to 15% compared to placebo. The softgel form offers easy absorption and convenience. Timeline is NSF Certified for Sport, making it suitable for athletes subject to drug testing. At around $2 per day, it’s premium-priced but backed by real science.
Pros:
- Only urolithin A with FDA GRAS status and multiple clinical trials
- NSF Certified for Sport—trusted by athletes
- 500mg clinically validated dose
- Swiss-engineered with 50+ global patents
Cons:
- Higher price point than generic alternatives
Best for: Anyone serious about longevity who wants the most scientifically validated option available.
2. Timeline Mitopure Gummies – Best Tasting
Why it stands out: Same patented Mitopure formula as the softgels, but in a delicious strawberry-flavored gummy format that makes daily supplementation enjoyable rather than a chore.
Timeline’s gummies deliver the full 500mg clinical dose of Mitopure urolithin A in a sugar-free, great-tasting format. They’re perfect for anyone who struggles with swallowing pills or simply prefers a more pleasant supplementation experience. The gummies maintain all the benefits of the original Mitopure—mitochondrial renewal, muscle support, and cellular energy. Each bottle provides a 30-day supply.
Pros:
- Delicious strawberry flavor
- Sugar-free formulation
- Same clinically proven Mitopure dose
- Easy to incorporate into daily routine
Cons:
- Slightly more expensive per serving than softgels
- Contains additional gummy ingredients
Best for: Anyone who dislikes swallowing pills or wants a more enjoyable supplement experience.
3. Codeage Liposomal Urolithin A – Best Synergistic Formula
Why it stands out: Codeage combines 500mg urolithin A with complementary longevity ingredients—trans-resveratrol, CoQ10, and betaine—in a liposomal delivery system designed for enhanced absorption.
This formula takes a multi-pronged approach to cellular health. The liposomal delivery uses phospholipids from non-GMO sunflower oil to help protect ingredients through digestion and improve bioavailability. You get urolithin A for mitophagy, resveratrol for sirtuin activation, CoQ10 for cellular energy production, and betaine for methylation support. It’s manufactured in a cGMP-certified facility in the USA and is vegan, non-GMO, gluten-free, and keto-friendly.
Pros:
- Synergistic blend of proven longevity compounds
- Liposomal delivery for enhanced absorption
- NSF certified for quality assurance
- Clean formula—vegan, non-GMO, allergen-free
Cons:
- Premium pricing
- Not as extensively clinically studied as Mitopure
Best for: Those who want a comprehensive cellular health formula rather than urolithin A alone.
4. Timeline Mitopure Powder – Best for Smoothies
Why it stands out: A versatile powder format that delivers 500mg of Mitopure urolithin A in delicious berry-vanilla flavor—perfect for mixing into smoothies, yogurt, or beverages.
Timeline’s powder sachets offer the same clinically validated Mitopure formula in a format that integrates seamlessly into your morning routine. Each sachet contains polyphenol-rich berry extracts that complement the urolithin A while adding natural flavor. The single-serve packets are convenient for travel and ensure accurate dosing. This is the format used in several of Timeline’s clinical studies.
Pros:
- Flexible dosing—mix into any beverage
- Great berry-vanilla flavor
- Travel-friendly single-serve sachets
- Same clinical backing as softgels
Cons:
- Requires mixing (not grab-and-go like softgels)
- Higher cost per serving
Best for: Smoothie lovers and those who prefer powders over pills.
5. NAD Supplement 8457mg with Urolithin A – Best Multi-Longevity Stack
Why it stands out: This comprehensive formula combines urolithin A with a full spectrum of longevity-supporting compounds including NMN, NAD+, resveratrol, CoQ10, alpha lipoic acid, and green tea extract.
Rather than taking multiple supplements, this all-in-one stack addresses cellular health from multiple angles. The urolithin A supports mitophagy while NMN and NAD+ precursors boost cellular energy metabolism. Resveratrol activates sirtuins, CoQ10 supports the electron transport chain, and alpha lipoic acid provides antioxidant protection. The liposomal delivery helps with absorption of these varied ingredients.
Pros:
- Comprehensive longevity stack in one product
- Multiple pathways to cellular health
- Good value compared to buying ingredients separately
- Liposomal delivery system
Cons:
- Individual ingredient doses may be lower than standalone products
- Less clinical validation for the specific combination
Best for: Those who want a simplified supplement regimen covering multiple longevity pathways.
6. Urolithin A Complex with NR – Best for Beginners
Why it stands out: A well-balanced introductory formula combining urolithin A with nicotinamide riboside (NR), resveratrol, CoQ10, PQQ, and L-theanine for comprehensive mitochondrial and cognitive support.
This 5-in-1 complex offers a gentler introduction to longevity supplementation. The formula combines urolithin A for mitophagy with NR (a NAD+ precursor), resveratrol for sirtuin support, CoQ10 for energy production, PQQ for mitochondrial biogenesis, and L-theanine for calm focus. It’s a thoughtfully designed stack that covers cellular energy, antioxidant protection, and cognitive function without overwhelming doses. Each bottle provides 60 servings.
Pros:
- Balanced doses of complementary ingredients
- Includes L-theanine for cognitive support
- Good entry point to longevity supplementation
- 60-day supply offers good value
Cons:
- Lower urolithin A dose than pure formulas
- Less specific for those targeting mitophagy
Best for: Beginners exploring longevity supplements who want a balanced, multi-benefit formula.
7. NMN Supplement 8957mg with Urolithin A – Best High-Potency Stack
Why it stands out: A powerhouse formula delivering real NAD+ (not just precursors) alongside urolithin A, resveratrol, CoQ10, alpha lipoic acid, and green tea extract for maximum cellular support.
This high-potency stack is designed for those who want aggressive support for cellular health and energy. The inclusion of actual NAD+ rather than just precursors may provide more direct benefits, though research on oral NAD+ bioavailability is still evolving. Combined with urolithin A for mitophagy and multiple antioxidants, this formula targets aging from multiple angles. Suitable for both men and women.
Pros:
- Contains actual NAD+ plus precursors
- High overall potency
- Multiple antioxidants included
- Good for experienced supplement users
Cons:
- May be too aggressive for beginners
- Higher price point
Best for: Experienced biohackers who want maximum cellular support.
8. MITIVA Urolithin A with NAD+ – Best Value
Why it stands out: A generous 120-softgel bottle combining urolithin A with NAD+, CoQ10, and PQQ at a competitive price point—offering excellent value for a multi-ingredient formula.
MITIVA delivers a solid mitochondrial support formula at a price that makes daily supplementation more accessible. The combination of urolithin A for mitophagy, NAD+ for cellular energy, CoQ10 for the electron transport chain, and PQQ for mitochondrial biogenesis covers the key bases of cellular health. The 120-softgel count provides a 2-month supply, bringing the daily cost well below premium brands.
Pros:
- 120 softgels—2-month supply
- Four key mitochondrial support ingredients
- Competitive pricing
- Softgel form for easy absorption
Cons:
- Less brand recognition than established players
- Individual ingredient doses may vary
Best for: Budget-conscious consumers who want a solid multi-ingredient formula.
9. Rasav NAD 10-in-1 with Urolithin A – Best Budget Multi-Nutrient
Why it stands out: A 10-ingredient formula combining urolithin A with NAD support compounds, resveratrol, CoQ10, green tea, and ALA at an accessible price point.
Rasav’s extra-strength formula packs 10 complementary ingredients into one supplement. You get urolithin A alongside NAD support, resveratrol, CoQ10, green tea extract, and alpha lipoic acid—covering antioxidant protection, cellular energy, and mitochondrial health. While individual doses may be lower than standalone products, the combination offers broad support at a fraction of the cost of buying each ingredient separately.
Pros:
- 10 longevity ingredients in one formula
- Very competitive pricing
- NMN supplement alternative
- Suitable for men and women
Cons:
- Lower doses of individual ingredients
- Less clinical validation for the combination
Best for: Budget shoppers who want comprehensive coverage without breaking the bank.
10. Prominent Nutrition Urolithin A + Fisetin – Best Pure Formula
Why it stands out: A clean, focused formula pairing 600mg urolithin A with fisetin—a senolytic compound that helps clear damaged cells—for a targeted approach to cellular health.
Prominent Nutrition takes a minimalist approach, combining just urolithin A and fisetin without the kitchen-sink formulas common in this space. Fisetin is gaining attention in longevity research for its senolytic properties—the ability to help clear senescent (damaged) cells. Paired with urolithin A’s mitophagy benefits, this formula targets cellular cleanup from two angles. It’s vegan, non-GMO, and gluten-free with a 30-day supply per bottle.
Pros:
- Higher urolithin A dose (600mg)
- Unique fisetin combination for senolytic support
- Clean, simple formula
- Vegan and allergen-free
Cons:
- Less clinical research on the UA + fisetin combination
- Smaller brand with less track record
Best for: Those who prefer focused formulas and are interested in senolytic support.
What is Urolithin A and Who Should Take It?
Urolithin A is a postbiotic compound that your body can produce when gut bacteria metabolize ellagitannins—polyphenols found in pomegranates, walnuts, and berries. However, research shows only about 40% of people have the specific gut bacteria needed to produce meaningful amounts. Even among producers, levels vary significantly based on individual microbiome composition. This biological lottery means most people simply cannot obtain therapeutic amounts of urolithin A from diet alone.
The compound works by triggering mitophagy—the cellular cleanup process that identifies, breaks down, and recycles damaged mitochondria. Think of it as quality control for your cells’ power plants. As we age, mitophagy naturally slows down, allowing dysfunctional mitochondria to accumulate. This contributes to reduced energy production, increased oxidative stress, and accelerated aging throughout the body. By stimulating mitophagy, urolithin A helps restore this cleanup process to more youthful levels.
Clinical research has documented measurable benefits in human subjects. A 2022 study published in Cell Reports Medicine showed that sedentary middle-aged adults taking 500mg of Mitopure daily for 4 months increased hamstring muscle strength by up to 12% compared to placebo. Another trial demonstrated improvements in exercise endurance of up to 15% after just 8 weeks. These aren’t marginal gains—they represent meaningful improvements in functional capacity.
Beyond muscle health, urolithin A may support cardiovascular function, cognitive health, and immune response through its effects on cellular energy metabolism. Preliminary research also suggests benefits for joint health by reducing inflammatory markers and supporting cartilage integrity. While more studies are needed in these areas, the foundational mechanism—improved mitochondrial function—has far-reaching implications.
Good candidates for urolithin A supplementation include adults over 40 concerned about age-related muscle loss (sarcopenia), those experiencing unexplained fatigue or reduced exercise capacity, athletes seeking improved recovery and performance, and anyone interested in evidence-based longevity interventions. It’s particularly valuable for people who don’t regularly consume pomegranates or may lack the gut bacteria for natural production—which statistically includes the majority of the population.
How to Choose the Right Urolithin A Supplement
Key Ingredients to Look For
Pure urolithin A should be the primary active ingredient, with clinical studies typically using 250-1000mg daily doses. The most researched form is Timeline’s Mitopure, which has FDA GRAS (Generally Recognized as Safe) status and multiple published human trials demonstrating efficacy. When evaluating products, look for supplements that clearly state the urolithin A content per serving rather than hiding it in proprietary blends.
Many formulas add complementary ingredients that target related pathways. Resveratrol activates sirtuins—proteins involved in cellular stress response and longevity. CoQ10 (ubiquinone or ubiquinol) directly supports the electron transport chain in mitochondria for energy production. NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) serve as precursors to NAD+, a crucial coenzyme for cellular metabolism. PQQ (pyrroloquinoline quinone) stimulates mitochondrial biogenesis—the creation of new mitochondria. These combinations may offer synergistic benefits, though they have less specific clinical validation than pure urolithin A.
Forms Compared
Softgels and capsules remain the most popular formats, offering convenience, accurate dosing, and good shelf stability. Simply swallow with water and you’re done. Standard capsules use vegetable cellulose or gelatin shells, while softgels typically contain the active ingredients suspended in oil, which may improve absorption of fat-soluble compounds.
Liposomal formulations represent a more advanced delivery technology. These products encapsulate active ingredients within phospholipid bubbles (liposomes) similar to cell membranes. In theory, this protects compounds from degradation in the digestive tract and enhances cellular uptake. While liposomal delivery has demonstrated benefits for certain nutrients like vitamin C, clinical studies specifically on liposomal urolithin A are limited.
Gummies have gained popularity for their palatability—they taste good and feel more like a treat than a supplement. However, they typically require additional ingredients like sugars, sweeteners, and gelling agents. Heat during manufacturing can also potentially degrade sensitive compounds. For urolithin A specifically, Timeline’s Mitopure gummies appear well-formulated, but generic gummy products may be less reliable.
Powders offer maximum flexibility—mix into smoothies, coffee, yogurt, or any beverage. They’re ideal for people who have trouble swallowing pills or want to customize their routine. The downside is the extra step of mixing, and some powders have unpleasant tastes that require masking with strongly flavored foods.
What to Avoid
Be cautious of products making exaggerated claims about immediate results—urolithin A benefits typically appear after 8-16 weeks of consistent use. Any supplement promising overnight transformation is likely overselling. Also watch out for formulas with proprietary blends that hide individual ingredient amounts; you deserve to know exactly what you’re taking and in what doses.
Extremely low prices often indicate inferior sourcing, inadequate testing, or outright adulteration. Producing quality urolithin A requires sophisticated manufacturing processes, and legitimate products simply cannot be sold for pennies per serving. Look for supplements with third-party testing, quality certifications (NSF, GMP, etc.), and transparent labeling.
Finally, understand that generic pomegranate extract is not equivalent to pure urolithin A. Pomegranate contains ellagitannins that must be converted by gut bacteria to urolithin A—a process that most people cannot complete efficiently. Taking pomegranate extract hoping to get urolithin A benefits is unreliable at best.
Side Effects and Precautions
Urolithin A has demonstrated an excellent safety profile across multiple clinical studies, with adverse events comparable to placebo groups. The compound has been used in human trials at doses up to 2000mg daily for extended periods without serious concerns. Timeline’s Mitopure has received FDA GRAS (Generally Recognized as Safe) status—a designation that requires substantial safety evidence.
The most commonly reported side effects are mild and digestive in nature. Some users experience occasional stomach discomfort, mild nausea, or changes in bowel habits during the initial weeks of supplementation. These effects typically resolve as the body adjusts and can often be minimized by taking urolithin A with food. Starting with a lower dose and gradually increasing may also help sensitive individuals adapt.
Certain populations should exercise extra caution. Pregnant and nursing women should avoid urolithin A supplements due to lack of safety data in these vulnerable populations—the compound simply hasn’t been studied enough in pregnancy to make confident safety claims. Children and adolescents should also avoid supplementation unless specifically recommended by a healthcare provider, as the effects on developing bodies haven’t been characterized.
Those taking medications should consult their healthcare provider before starting urolithin A. Pomegranate-derived compounds may interact with certain drugs, particularly blood thinners (warfarin, etc.), immunosuppressants, and medications metabolized by CYP3A4 liver enzymes. There’s theoretical concern about enhanced anticoagulant effects, though this hasn’t been documented with pure urolithin A. People with severe kidney or liver disease should seek medical guidance, as these organs handle supplement metabolism and excretion.
While urolithin A is generally well-tolerated by healthy adults, anyone with serious health conditions should discuss supplementation with their doctor. This is especially true for those managing chronic diseases, taking multiple medications, or preparing for surgery (some practitioners recommend stopping supplements 2 weeks before procedures).
FAQs
What dose of urolithin A is most effective?
Clinical studies have used doses ranging from 250mg to 1000mg daily, with 500mg being the most common and well-studied dose. Timeline’s research shows benefits at 500mg, which is why most quality supplements target this amount. Higher doses haven’t necessarily shown better results in trials.
How long does it take to notice benefits from urolithin A?
Most people begin noticing subtle improvements in energy and exercise capacity within 4-8 weeks. However, the clinical trials showing significant muscle strength improvements ran for 4 months, suggesting that longer-term use yields more meaningful benefits. Consistency is key.
Should I take urolithin A with food?
Taking urolithin A with food may improve absorption and reduce any digestive discomfort, though it’s not strictly required. Some liposomal formulations are designed to be taken without food. Follow the specific instructions on your product.
Can I get enough urolithin A from pomegranate juice?
Probably not. While pomegranates contain the precursor compounds, only about 40% of people can convert them to urolithin A efficiently. Even among converters, you’d need to consume large amounts daily. Timeline estimates their 500mg Mitopure dose delivers 6x more urolithin A than a glass of pure pomegranate juice.
Is urolithin A safe to take with other supplements?
Urolithin A is generally safe to combine with most supplements. It’s commonly stacked with other longevity compounds like NMN, resveratrol, and CoQ10—in fact, many products include these combinations. However, if you’re taking medications, consult your healthcare provider about potential interactions.
Who should avoid urolithin A supplements?
Pregnant and breastfeeding women should avoid urolithin A due to insufficient safety data. People with severe kidney or liver disease should consult their doctor first. Those on blood thinners or immunosuppressive medications should also seek medical guidance, as pomegranate compounds may have interactions.
What’s the difference between urolithin A and pomegranate extract?
This is a crucial distinction. Pomegranate extract contains ellagitannins—precursor compounds that gut bacteria must convert into urolithin A. The problem is that most people lack the specific bacteria to complete this conversion efficiently. Pure urolithin A supplements bypass this conversion entirely, delivering the active compound directly. Taking pomegranate extract hoping to get urolithin A benefits is like hoping your body will convert beta-carotene to vitamin A—it might happen, but you’re better off taking the end product.
Can urolithin A help with weight loss or metabolism?
While urolithin A isn’t a direct weight loss supplement, improved mitochondrial function can support overall metabolic health. Better-functioning mitochondria are more efficient at producing cellular energy and burning fuel. Some users report improved exercise capacity and recovery, which may indirectly support body composition goals. However, urolithin A shouldn’t be viewed as a fat burner—its primary benefits relate to cellular health and muscle function.
Final Verdict
For most people seeking the best urolithin A supplement, Timeline Mitopure Softgels is our top recommendation. It’s the only urolithin A with multiple published clinical trials, FDA GRAS status, and NSF Certified for Sport designation. The 500mg dose is clinically validated, and the company’s 15+ years of research and 50+ patents provide confidence in quality.
If budget is a concern, MITIVA Urolithin A with NAD+ offers solid value with a 2-month supply of multi-ingredient mitochondrial support at a competitive price. For those who prefer a comprehensive longevity stack in one product, Codeage Liposomal Urolithin A combines urolithin A with resveratrol, CoQ10, and enhanced absorption technology.
The best choice ultimately depends on your specific goals, budget, and whether you prefer pure urolithin A or a synergistic combination formula. Whichever you choose, consistency matters more than chasing the “perfect” product—pick one and stick with it for at least 3-4 months to evaluate results.
